Ehlers-Danlos Syndrome (EDS) can make daily life feel like walking a tightrope — every joint a potential point of pain, instability, or injury. At Alleviate Pain Clinic, we approach EDS-related ligament laxity with advanced image-guided regenerative therapies like PRP and Prolotherapy, tailored for long-term stability and functional restoration.
What is Ehlers-Danlos Syndrome?
Ehlers-Danlos Syndrome (EDS) is a group of connective tissue disorders caused by genetic defects in collagen synthesis. Collagen is crucial for tissue strength and elasticity. In EDS, faulty collagen leads to:
- Hypermobile joints
- Stretchy, fragile skin
- Poor wound healing
- Chronic pain and joint instability
One of the most debilitating aspects of EDS is ligamentous laxity, which leads to joint subluxations, dislocations, and long-term degenerative changes.
Clinical Features of Ligament Laxity in EDS
Ligament laxity refers to the loosening or weakening of ligaments — the connective tissue that stabilizes joints. In EDS, this results in:
1. Frequent Joint Subluxations or Dislocations
- Often from minor movements
- Can be spontaneous and recurrent
2. Pain and Muscle Fatigue
Due to constant compensation for unstable joints
3. Chronic Inflammation
Secondary to microtrauma and abnormal joint loading
4. Early-Onset Degenerative Joint Changes
Especially in weight-bearing joints
Joints Commonly Affected by Ligament Laxity in EDS
EDS doesn’t restrict itself to one area — it affects multiple joints throughout the body:
Joint | Symptoms |
|---|---|
Shoulder | Subluxations, rotator cuff pain, impingement |
Knee | Patellar instability, meniscal strain, early arthritis |
Ankle | Chronic sprains, lateral ligament laxity |
Hip | Labral tears, instability, bursitis |
Wrist & Fingers | Subluxation, trigger fingers, grip weakness |
Temporomandibular | Clicking, jaw instability, facial pain |
Spine | Instability, fatigue, postural issues, headaches (cervical) |
Over time, such instability leads to compensatory muscle overuse, biomechanical dysfunction, and a significant reduction in quality of life.
Goals of Treatment at Alleviate Pain Clinic
EDS cannot be cured, but ligament laxity and joint instability can be significantly improved with a multidisciplinary and regenerative approach:
- Stabilize hypermobile joints
- Reduce chronic pain
- Prevent further degeneration
- Improve posture and function
- Enhance overall quality of life
Image-Guided PRP & Prolotherapy: Targeted Regeneration
Image guided Intrarticular Shoulder joint Platelet Rich Plasma Injection done along with prolotherapy at Alleviate Pain Clinic, Bengaluru for a patient suffering with Recurrent Shoulder Dislocations due to laxity caused by Ehlers Danlos syndrome. Image- Courtesy Alleviate Pain Clinic
Image guided Intrarticular Ankle joint Platelet Rich Plasma Injection done along with prolotherapy at Alleviate Pain Clinic, Bengaluru for a patient suffering with Recurrent Ankle Sprains due to laxity caused by Ehlers Danlos syndrome. Image- Courtesy Alleviate Pain Clinic
PRP (Platelet-Rich Plasma) Therapy
PRP uses concentrated platelets from your own blood, injected into lax or injured ligaments under ultrasound or fluoroscopic guidance. Growth factors in PRP:
- Stimulate collagen synthesis
- Enhance ligament healing
- Improve tensile strength and joint stability
Prolotherapy (Proliferative Therapy)
Prolotherapy involves injecting a mild irritant solution (usually dextrose-based) into the affected ligament or tendon insertion to:
- Stimulate a healing cascade
- Promote fibroblast activity
- Induce controlled inflammation to strengthen the connective tissue
At Alleviate, image guidance ensures accurate needle placement and maximum therapeutic benefit, reducing risk and enhancing outcomes.
Why a Multidisciplinary Approach is Critical
EDS affects more than just ligaments. That’s why Alleviate Pain Clinic provides a comprehensive treatment protocol involving:
Pain Specialists
- Administer PRP & Prolotherapy
- Guide pharmacologic pain relief if needed
Physiotherapists
- Tailored strengthening and proprioceptive training
- Focus on postural corrections and joint protection
Clinical Nutritionists
- Provide collagen-boosting diets
- Optimize anti-inflammatory nutrients
Clinical Psychologists
- Help manage chronic pain fatigue and anxiety
- Support mental health resilience
Orthopedic Collaborations
- In complex cases requiring surgical referral
What Can Patients Expect?
Most patients undergoing PRP and Prolotherapy for EDS-related ligament laxity report:
- Reduced frequency of subluxation/dislocations
- Improved joint confidence during daily movements
- Less fatigue and muscle overcompensation
Improved participation in physical and social activities
Why Choose Alleviate Pain Clinic?
At Alleviate Pain Clinic, we combine cutting-edge regenerative techniques with expert diagnostics, image guidance, and compassionate care.
- Advanced C-arm & Ultrasound-guided interventions
- Custom PRP formulations for connective tissue
- Experience with EDS and other hypermobility syndromes
- Integrated rehab & lifestyle management protocols
Take the First Step
If you or your loved one is living with joint instability due to Ehlers-Danlos Syndrome, don’t wait for pain and degeneration to take over.
Contact Alleviate Pain Clinic today to book your consultation and explore how PRP and Prolotherapy can help you live a more stable, confident life.
